Jun 6, 2025 · In September 2023, VG-3927 became the first small-molecule TREM-2 agonist cleared to enter the clinic. In October 2023, the first volunteer was treated in a Phase 1, …

Apr 17, 2025 · TREM2 created quite the buzz at this year’s AD/PD meeting, held April 1-5 in Vienna. In the wake of a TREM2 agonist’s demise, scientists presented optimistic findings …

TREM2 encodes Triggering Receptor Expressed on Myeloid Cells 2, a transmembrane receptor that modulates microglial activity and survival. TREM2 variants cause Nasu-Hakola disease …

Since the discovery of rare, yet potent risk variants in the TREM2 gene 11 years ago, the microglial receptor has emerged as a pivot point in the pathogenesis of Alzheimer’s disease. …

Apr 26, 2024 · This insightful paper by the Schwartz lab delves into the analysis of microglia in Alzheimer’s disease (AD) and aging models, shedding light on intriguing findings. The key …

Nov 26, 2012 · Identification of soluble TREM-2 in the cerebrospinal fluid and its association with multiple sclerosis and CNS inflammation. Brain. 2008 Nov;131 (Pt 11):3081-91.

Jan 18, 2018 · The Trem2 −/− (KOMP) mouse was created by the NIH Knockout Mouse Project. In this Trem2 knockout line, the entire coding region of the mouse Trem2 gene was replaced …

Jan 20, 2023 · It is very intriguing that the ATV:TREM2-activating antibody enhances brain exposure and pharmacodynamic microglial responses compared to an anti-TREM2 antibody. …

Nov 3, 2023 · Zhang X, Tang L, Yang J, Meng L, Chen J, Zhou L, Wang J, Xiong M, Zhang Z. Soluble TREM2 ameliorates tau phosphorylation and cognitive deficits through activating …

Sep 12, 2022 · Zhao P, Xu Y, Jiang L, Fan X, Li L, Li X, Arase H, Zhao Y, Cao W, Zheng H, Xu H, Tong Q, Zhang N, An Z. A tetravalent TREM2 agonistic antibody reduced amyloid pathology in …