It was a rough week of picks for the Sports Illustrated team as upsets happened throughout the NFL, and Iain MacMillan was the only one to walk away from Week 1

This article was originally published on www.fansided.com as NFL Week 15 picks and predictions, straight-up and ATS: Bills-Patriots, Packers-Broncos lead huge slate.

We never lost faith in the Buffalo Bills last week, even when they fell behind by 21 points in New England, and correctly predicted the Philadelphia Eagles and Houston Texans would win by double digits. However, old man Philip Rivers cost us some money in his return to the field, and my patience with the Dallas Cowboys has clearly worn thin.

Nick Simon brings you his favorite picks for FanDuel’s Monday night single-game DFS contests.

The Kansas City Chiefs and Tennessee Titans meet Sunday in Week 16 in Nashville, Tennessee, with kickoff slated for 1 p.m. ET.

Now, he's going up against a Jets defense that just allowed Trevor Lawrence to post six total touchdowns (five passing and one rushing), which led to the firing of defensive coordinator Steve Wilks. Shough shouldn't face much resistance this week, which could make it very hard for undrafted rookie Brady Cook to keep up in his second career start.

Week 16 of the NFL season began Thursday night with a wild overtime game between the LA Rams and Seattle Seahawks. On Saturday, there were two games. There will be a Sunday night and a Monday night game.