The process of drug disposition can be divided into four parts — absorption, distribution, metabolism and excretion. Drug interactions can occur throughout the process of disposition as a result of ...

A research team led by Kobe University Graduate School of Medicine's Professor OGAWA Wataru (the Division of Diabetes and Endocrinology) and Project Associate Professor NOGAMI Munenobu (the Department ...

Most of the enzymes involved in drug metabolism are present in the liver. This means the liver plays a key role in drug metabolism. Drug metabolism occurs when the body chemically alters drugs so it ...

Renal drug excretion involves filtration, reabsorption, and secretion, crucial for drug clearance and minimizing toxicity. The study models renal clearance using pharmacokinetic parameters, validated ...

When a drug is absorbed and enters the systemic circulation, it is naturally distributed throughout the fluid and tissues in the body. Drug distribution is a subject that is covered in a branch of ...

Drug discovery is a high-risk, high-cost endeavor, with over 90% of candidates failing in clinical development. A significant proportion of these failures stem from unresolved biopharmaceutic ...